Endocrine Abstracts

Introduction: Niemann Pick disease is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in acid sphingomyelinase. Usually discovered in childhood, it can affect liver, spleen and pulmonary function. Here, we report the case of a Niemann Pick type B disease in an adult associated with bilateral adrenal incidentalomas.Observation: A 45-year-old male patient was found to have bilateral adrenal incidentalomas associated with hepato...

Background: Pituitary metastasis are rare, however, not well-documented. They are usually encountered in elderly patients with disseminated malignant disease. The most frequent are metastases of breast and lung cancer. We herein report a case of an old patient with pituitary metastasis of a mediastinal lymphoma.Case report: A 88-year-old man with a history of treated prostate cancer and primary hypothyroidism presented to our emergency department with he...

Neuromedin B (NB) is a peptide highly expressed in adipose tissue (AT) but its function remains unclear. We showed that NB receptor (NB) knockout mice (NBR-KO) are resistant to diet-induced obesity compared to wild type (WT) and now we aimed to analyze NBR influence in adipocytes. Mesenchimal cells from perigonadal AT of WT and NBR-KO mice were isolated and maintained in growth medium (GM) as control group or in differentiation medium (DM) as induced group. After 2 weeks cells...

Aim of the study: To test B-Lymphocyte Stimulator (BLyS) as a new serological marker in the follow-up of patients with neuroendocrine tumors (NET).Methods: Eighty-one consecutive patients with NET and 56 age and sex-matched controls were enrolled in the study. According to the clinical course, patients were classified in 2 subgroups: evidence of persistent but stable disease or in remission (n=45) and patients with evidence of recurrent disease (p...

Introduction: Aminoterminal pro B type natriuretic peptide (NT-pro BNP) is the inactive degradation product of pro BNP. Thyroid diseases are known to have effect on NT-pro BNP levels. In this study, we aimed to determine possible changes in NT-pro BNP levels in patients with thyroid dysfunctions.Material and method: Fifteen patients with hyperthyroidism, 8 with subclinical hyperthyroidism, 12 with hypothyroidism, 15 with subclinical hypothyroidism and 35...

Neuromedin B (NMB) is a highly conserved bombesin-related peptide found in mammals. The mammalian bombesin family of receptors consists of three closely related G protein coupled receptors, BB1, BB2 and BB3. The BB1 receptor subtype has the highest affinity for NMB. NMB mRNA is detected in the CNS and is expressed at relatively high levels in the rat hypothalamus, in particular the medial preoptic area and the arcuate nucleus.<p ...

The major source of neurokinin B (NKB), a peptide of the tachykinin family, is the placenta. Little is known of the regulation of NKB or its preferred hypertensive-inducing receptor, NK3, during pregnancy, nor, the mechanisms leading to elevated NKB associated with pre-eclampsia (PE) during the third trimester. Using the pregnant rat we have looked at the changes in NKB and NK3 expression using real time PCR between day 16 and 21 of gestation in the placenta, brain and differe...

Introduction: Radioiodine (Iodine-131) is a widely used treatment for thyrotoxicosis. Fluctuation in thyroid hormone levels following radioiodine treatment is common. Hypothyroidism occurs in approximately 5.5% of patients per month in the first 6 months, with onset time hard to predict. In contrast, some patients remain hyperthyroid either due to persistent pre-radioiodine thyrotoxicosis or transient exacerbation following radioiodine. We examined whether the block & repl...

Aim: Cardiovascular disease is more common in individuals with diabetes mellitus and obesity. Visfatin is elevated in obesity and T2DM; and thought to be an inflammatory mediator within atherosclerotic lesions inducing gelatinase activity, contributing to plaque destabilisation. We investigated the activation of NF-κB, a well-known pro-inflammatory transcription factor, by visfatin, in Human Endothelial Cells (EC).Research design and methods: We sta...

Intravascular Large B-Cell lymphoma (IVLBCL) is an extremely rare type of non-Hodgkin lymphoma involving the growth of lymphoma cells within the vessel lumen without lymphadenopathy. As disease has various modes of presentation and is exceptionally rare, IVLBCL is often diagnosed postmortem. Herein, we report a case of IVLBCL with hypopituitarism, an extremely rare complication, that was successfully treated with chemotherapy. 60 years old woman noticed redness of the abdomen,...